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Ritonavir or lopinavir/ritonavir significantly raise plasma concentrations of oxycodone in healthier human volunteers because of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin significantly decreases plasma concentrations of oxycodone as a result of solid induction of CYP3A4.Canadian oxycodone HCL/acetaminophen five/325 mg tablet In February 2012,
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